ADME (Drug Absorption, Distribution, Metabolism, and Excretion) represents crucial aspects of drug development, encompassing Absorption, Distribution, Metabolism, and Excretion within the body. These facets serve as pivotal indicators for evaluating a drug's pharmacokinetic properties. LeadQuest Biotech offers comprehensive ADME solutions.

List of Service Available

• Solubility (Kinetic Solubility, Thermodynamic Solubility)
• Lipophilicity (LogD, LogP)
• Stability (Chemical Stability, Whole Blood Stability, Plasma Stability, Liver Microsome/S9 Stability, Single Enzyme Stability, Primary Hepatocyte Stability, etc.)
• Parallel Artificial Membrane Permeability Assay
• Metabolite Identification
• Drug-drug Interaction (IC50, Time-Dependent Inhibition (TDI), Inhibition Constant (Ki))
• Transporter Assays (SLC, ABC)
• Plasma/Tissue Protein Binding (Equilibrium Dialysis, Ultracentrifugation, Ultrafiltration)
• Whole Plasma Partition Coefficient
• Pharmacokinetics (PK) for Rats, Mice, and Dogs (Standard PK, Rapid PK, Box PK, Snapshot PK, Tissue Distribution, Central Nervous System (CNS) PK, Solvent Optimization)
• Acute Toxicity Assessment
• Endogenous Substance Analysis

Comprehensive Drug Efficacy Evaluation Services